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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK1
All Species:
38.79
Human Site:
T49
Identified Species:
71.11
UniProt:
P57059
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P57059
NP_775490.2
783
84902
T49
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Chimpanzee
Pan troglodytes
XP_531484
783
84972
T49
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_544912
898
97147
T174
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Cat
Felis silvestris
Mouse
Mus musculus
Q60670
779
85009
T49
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Rat
Rattus norvegicus
Q9R1U5
776
84890
T49
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
T48
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Chicken
Gallus gallus
Q9IA88
798
88848
T48
K
L
A
R
H
R
V
T
K
T
Q
V
A
I
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
T81
K
L
A
T
H
M
I
T
K
A
K
V
A
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
T163
K
L
A
R
H
R
I
T
K
N
E
V
A
I
K
Honey Bee
Apis mellifera
XP_397175
718
80391
D49
E
V
A
I
K
I
I
D
K
T
Q
L
D
P
T
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
T192
K
L
A
K
H
V
I
T
G
H
E
V
A
I
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
N.A.
69.2
N.A.
81.3
81.6
N.A.
70.4
66.6
N.A.
32
N.A.
28.8
36.5
24.5
N.A.
Protein Similarity:
100
99.6
N.A.
73.6
N.A.
86.2
86.3
N.A.
77
76.6
N.A.
44
N.A.
38
50.9
39.4
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
N.A.
66.6
N.A.
80
26.6
60
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
N.A.
80
N.A.
93.3
53.3
80
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
27.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41
42.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
85
0
0
0
0
0
0
8
0
0
77
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% G
% His:
0
0
0
0
77
0
0
0
0
8
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
8
31
0
0
0
0
0
0
77
0
% I
% Lys:
77
0
0
8
8
0
0
0
77
0
8
0
0
0
77
% K
% Leu:
0
77
0
0
0
0
0
0
0
0
0
8
0
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
62
0
0
0
0
% Q
% Arg:
0
0
0
62
0
62
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
0
77
0
62
0
0
0
0
8
% T
% Val:
0
8
0
0
0
8
54
0
0
0
0
77
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _